Which TNF inhibitor has an intravenous dosing option of 2 mg/kg?

Which TNF inhibitor has an intravenous dosing option of 2 mg/kg?

• A. Adalimumab
• B. Etanercept
• C. Golimumab
• D. Certolizumab

Answer: (C)

TNF inhibitors differ in how you give them and how the dose is determined. Among these agents, only one is given intravenously with a weight-based dose of 2 mg/kg. This IV regimen is administered as an infusion at the start and again at week 4, then every 8 weeks thereafter. The other drugs are used mainly as subcutaneous injections with fixed dosing schedules: one is given as 40 mg SC every other week, another as 50 mg SC weekly, and the last with loading doses of 400 mg at weeks 0, 2, and 4 followed by 200 mg every 2 weeks. So the 2 mg/kg IV option specifically points to golimumab.

TNF inhibitors differ in how you give them and how the dose is determined. Among these agents, only one is given intravenously with a weight-based dose of 2 mg/kg. This IV regimen is administered as an infusion at the start and again at week 4, then every 8 weeks thereafter. The other drugs are used mainly as subcutaneous injections with fixed dosing schedules: one is given as 40 mg SC every other week, another as 50 mg SC weekly, and the last with loading doses of 400 mg at weeks 0, 2, and 4 followed by 200 mg every 2 weeks. So the 2 mg/kg IV option specifically points to golimumab.