Which statement about hydration is correct for preventing stones when using Sulfasalazine?

Which statement about hydration is correct for preventing stones when using Sulfasalazine?

• A. Ensure adequate hydration to prevent stone formation.
• B. Avoid hydration to prevent stone formation.
• C. Hydration is not necessary.
• D. Hydration should be replaced with a diuretic.

Answer: (A)

Hydration helps prevent stones because sulfasalazine and its metabolites can crystallize in urine if it becomes concentrated. Keeping urine well diluted by drinking plenty of fluids increases urine flow, reducing the chance that crystals form and grow into stones. This simple measure directly lowers stone risk during therapy. Avoiding fluids would raise stone risk, and hydration isn’t unnecessary. Replacing hydration with a diuretic isn’t a substitute for fluids and doesn’t adequately prevent crystal formation.

Hydration helps prevent stones because sulfasalazine and its metabolites can crystallize in urine if it becomes concentrated. Keeping urine well diluted by drinking plenty of fluids increases urine flow, reducing the chance that crystals form and grow into stones. This simple measure directly lowers stone risk during therapy.

Avoiding fluids would raise stone risk, and hydration isn’t unnecessary. Replacing hydration with a diuretic isn’t a substitute for fluids and doesn’t adequately prevent crystal formation.