Which of the following is NOT listed as an offending agent for SJS/TENS?

Which of the following is NOT listed as an offending agent for SJS/TENS?

• A. Opiates
• B. Sulfonamides
• C. Penicillins
• D. Allopurinol

Answer: (A)

SJS/TEN are immune-mediated reactions where certain drugs trigger widespread keratinocyte death leading to skin and mucous membrane detachment. Among the drugs commonly listed as culprits are sulfonamides, penicillins, and allopurinol—each of these is repeatedly reported as a high-risk trigger, especially in susceptible individuals. Opiates, while they can cause various adverse effects, are not typically listed as common offenders for SJS/TEN in standard references and case compilations. Therefore, opiates are the drug class that is not listed as a typical triggering agent for these severe reactions.

SJS/TEN are immune-mediated reactions where certain drugs trigger widespread keratinocyte death leading to skin and mucous membrane detachment. Among the drugs commonly listed as culprits are sulfonamides, penicillins, and allopurinol—each of these is repeatedly reported as a high-risk trigger, especially in susceptible individuals. Opiates, while they can cause various adverse effects, are not typically listed as common offenders for SJS/TEN in standard references and case compilations. Therefore, opiates are the drug class that is not listed as a typical triggering agent for these severe reactions.