Which of the following is NOT listed among older DMARD agents?

Which of the following is NOT listed among older DMARD agents?

• A. Gold Salts
• B. Penicillamine
• C. Methotrexate
• D. Azathioprine

Answer: (C)

Distinguishing older DMARDs from more recently introduced ones is the idea here. Gold salts and penicillamine were among the first DMARDs used for rheumatoid arthritis, known for their effectiveness but also for substantial toxicity and monitoring needs. Azathioprine is another older immunosuppressant with DMARD activity that researchers and clinicians used before newer agents became standard. Methotrexate, while a central DMARD today, entered clinical use later and is considered a newer-generation option due to its more recent adoption and broad, potent efficacy. So methotrexate is not listed among the older DMARDs, which is why it’s the correct choice.

Distinguishing older DMARDs from more recently introduced ones is the idea here. Gold salts and penicillamine were among the first DMARDs used for rheumatoid arthritis, known for their effectiveness but also for substantial toxicity and monitoring needs. Azathioprine is another older immunosuppressant with DMARD activity that researchers and clinicians used before newer agents became standard. Methotrexate, while a central DMARD today, entered clinical use later and is considered a newer-generation option due to its more recent adoption and broad, potent efficacy. So methotrexate is not listed among the older DMARDs, which is why it’s the correct choice.