Which is the usual daily dose of Leflunomide?

Which is the usual daily dose of Leflunomide?

• A. 50 mg daily.
• B. 10-20 mg daily.
• C. 100 mg weekly.
• D. 1-2 mg daily.

Answer: (B)

Leflunomide is a DMARD used for rheumatoid arthritis, and after an initial loading phase to reach therapeutic levels quickly, the usual daily maintenance dose is in the 10–20 mg range. This keeps drug exposure effective while balancing potential side effects. A common approach is a short loading course of 100 mg daily for a few days, then continuing with 10–20 mg once daily. The other options are not typical: 50 mg daily is higher than standard maintenance and increases risk of toxicity; 100 mg weekly doesn’t fit how the drug is dosed; and 1–2 mg daily is far too low to maintain therapeutic levels.

Leflunomide is a DMARD used for rheumatoid arthritis, and after an initial loading phase to reach therapeutic levels quickly, the usual daily maintenance dose is in the 10–20 mg range. This keeps drug exposure effective while balancing potential side effects. A common approach is a short loading course of 100 mg daily for a few days, then continuing with 10–20 mg once daily. The other options are not typical: 50 mg daily is higher than standard maintenance and increases risk of toxicity; 100 mg weekly doesn’t fit how the drug is dosed; and 1–2 mg daily is far too low to maintain therapeutic levels.