What is a common adverse drug reaction associated with JAK inhibitors?

What is a common adverse drug reaction associated with JAK inhibitors?

• A. Increase cholesterol
• B. Nausea
• C. Hair loss
• D. Kidney failure

Answer: (A)

JAK inhibitors commonly cause dyslipidemia, with an elevation in cholesterol seen after starting therapy. This lipid increase is a well-documented and frequently observed adverse effect across multiple agents in this class, usually appearing within weeks to months. Among the options, increased cholesterol best fits the typical adverse reaction profile for JAK inhibitors. While nausea can occur, it’s less characteristic, and hair loss or kidney failure are not commonly associated with this drug class. Regular lipid monitoring is advised, with management of elevated levels as needed.

JAK inhibitors commonly cause dyslipidemia, with an elevation in cholesterol seen after starting therapy. This lipid increase is a well-documented and frequently observed adverse effect across multiple agents in this class, usually appearing within weeks to months. Among the options, increased cholesterol best fits the typical adverse reaction profile for JAK inhibitors. While nausea can occur, it’s less characteristic, and hair loss or kidney failure are not commonly associated with this drug class. Regular lipid monitoring is advised, with management of elevated levels as needed.