JAK inhibitors include which agents?

JAK inhibitors include which agents?

• A. Tofacitinib
• B. Rituximab
• C. Abatacept
• D. Adalimumab

Answer: (A)

JAK inhibitors block the intracellular JAK-STAT signaling pathway, which transmits many inflammatory signals inside cells. They are small-molecule drugs taken orally, unlike biologics that target extracellular molecules. Among the options, tofacitinib is the JAK inhibitor because it directly inhibits JAK enzymes, reducing downstream STAT activation and inflammatory gene expression. The other agents are different types of immunomodulators: rituximab depletes B cells by targeting CD20, abatacept blocks T-cell co-stimulation, and adalimumab neutralizes TNF-alpha. So, the only JAK inhibitor listed is tofacitinib.

JAK inhibitors block the intracellular JAK-STAT signaling pathway, which transmits many inflammatory signals inside cells. They are small-molecule drugs taken orally, unlike biologics that target extracellular molecules. Among the options, tofacitinib is the JAK inhibitor because it directly inhibits JAK enzymes, reducing downstream STAT activation and inflammatory gene expression. The other agents are different types of immunomodulators: rituximab depletes B cells by targeting CD20, abatacept blocks T-cell co-stimulation, and adalimumab neutralizes TNF-alpha. So, the only JAK inhibitor listed is tofacitinib.