Indomethacin IR dosing is which of the following?

Indomethacin IR dosing is which of the following?

• A. IR: 25-50 mg PO BID
• B. IR: 100 mg QD
• C. IR: 5-10 mg PO daily
• D. ER: 75 mg PO daily

Answer: (A)

Indomethacin IR is a short-acting NSAID, so it’s given in divided doses to maintain pain relief and minimize stomach irritation. The typical regimen is 25–50 mg by mouth two to three times daily, which usually totals about 50–100 mg per day. This is why the standard IR dosing described is 25–50 mg taken twice daily. The other patterns don’t fit IR use: 100 mg once daily isn’t typical for an immediate-release form because the effect wears off before 24 hours; 5–10 mg once daily is too small to provide adequate analgesia; and an ER (extended-release) formulation is designed for once-daily dosing and isn’t the IR regimen.

Indomethacin IR is a short-acting NSAID, so it’s given in divided doses to maintain pain relief and minimize stomach irritation. The typical regimen is 25–50 mg by mouth two to three times daily, which usually totals about 50–100 mg per day. This is why the standard IR dosing described is 25–50 mg taken twice daily.

The other patterns don’t fit IR use: 100 mg once daily isn’t typical for an immediate-release form because the effect wears off before 24 hours; 5–10 mg once daily is too small to provide adequate analgesia; and an ER (extended-release) formulation is designed for once-daily dosing and isn’t the IR regimen.